Botulax: Wholesale Supply & Bulk Pricing
Botulax® (also known globally as Letybo®) is a highly purified LetibotulinumtoxinA neurotoxin produced by Hugel Inc. in South Korea. Serving as the #1 market-leading Botox for 9 consecutive years, it offers exceptional 900 kDa efficacy for both aesthetic lines and therapeutic spasticity. Clinics can buy Botulax in bulk to ensure premium, FDA-approved quality with strict cold-chain shipping.
- What is Botulax® & Corporate Profile
- Mechanism of Action & Composition
- Target Areas & Indications
- Product Variants (100U vs 200U vs 300U)
- Preparation & Dosage Protocol
- Clinical Advantages & Trial Data
- Visible Improvements (Before & After)
- Why Buy Botulax Bulk from Us?
- Storage, Shelf Life & Safety
- R&D and Future Pipeline
- Frequently Asked Questions (FAQ)
What is Botulax® & Corporate Profile
Botulax® (commercially known as Letybo® in the US, Europe, and other specific markets) is a globally recognized botulinum toxin type A product developed by the pharmaceutical giant Hugel, Inc. in South Korea. Extracted from the Clostridium botulinum CBFC26 strain, it stands as a cornerstone in medical aesthetics.
Corporate Ascendancy & Quality Standards: Hugel has established Botulax as the absolute market leader in South Korea, maintaining the #1 market share for nine consecutive years since 2016. It is the first and only Korean toxin to penetrate the world's three largest markets: the US, China, and Europe.
With an export footprint in over 70 countries, manufacturing takes place in Chuncheon at the Geodu and Sinbuk facilities. The product boasts uncompromising global certifications including KGMP, European EMA GMP (2021), and the highly rigorous US FDA cGMP (2024), guaranteeing practitioners the highest level of trust when sourcing this premium Botox alternative.
Global Standard PDF
Review the official Botulax Global Standard brochure for comprehensive manufacturer specifications.
View PDF ➔Official Brochure
Explore clinical data, mechanism details, and aesthetic applications in the Letybo/Botulax brochure.
View PDF ➔Mechanism of Action & Composition
Botulax exerts its action directly at the neuromuscular junction, interrupting nerve signaling precisely where needed.
How Botulax Works:
LetibotulinumtoxinA binds to nerve endings and inhibits the release of acetylcholine (a key neurotransmitter) at the neuromuscular junction. This targeted blockade prevents muscle contractions, leading to localized, temporary paralysis. As a result, the overlying skin relaxes, dynamically smoothing out severe wrinkles and alleviating therapeutic spasticity.
Formulation Details (Per 100U Flacon):
- Active Ingredient: 100 U Clostridium Botulinum Toxin Type A (approx. 900 kDa molecular weight including complex proteins). Contains less than 2.5 ng/flacon of neurotoxin protein.
- Human Serum Albumin (0.5 mg): Used as an excipient to stabilize the complex structure.
- Sodium Chloride (0.9 mg): Ensures optimal isotonicity and stabilizes the formulation.
- Form: White, freeze-dried (vacuum-dried) powder in a colorless, transparent glass vial.
Target Areas & Indications
Clinics frequently order Botulax due to its incredibly versatile scope, bridging the gap between premium aesthetic cosmetics and serious medical treatments.
Approved Aesthetic Uses
- Glabellar Lines: Temporary correction of moderate to severe vertical lines between the eyebrows in adults.
- Crow's Feet: Smoothing of lateral canthal lines caused by orbicularis oculi muscle activity.
Approved Therapeutic Uses
- Benign Essential Blepharospasm: Eyelid spasm treatment for adults over 18.
- Pediatric Cerebral Palsy: Treating dynamic equinus foot deformity caused by spasticity in children 2 years and older.
- Post-Stroke Spasticity: Upper limb spasticity management in adults over 20 years old.
*Clinical trials for cervical dystonia, overactive bladder, and benign masseteric hypertrophy are currently ongoing.
Product Variants (100U vs 200U vs 300U)
Botulax is available in varying dosages to meet specific clinic demands, ensuring minimum wastage and maximum procedural efficiency.
Botulax 100 Units
Ideal For: Standard aesthetic facial treatments (frown lines, crow's feet, forehead). The industry staple for individual patient appointments.
Botulax 200 Units
Ideal For: High-volume practices treating masseter hypertrophy (jawline slimming), hyperhidrosis, or servicing multiple back-to-back aesthetic patients. Excellent ROI when you buy Botulax in bulk.
Botulax 300 Units
Ideal For: Heavy therapeutic indications such as post-stroke upper limb spasticity and pediatric cerebral palsy, requiring massive localized dosing protocols.
*50U and 150U formats are also manufactured for niche dosing requirements.
Preparation & Dosage Protocol
Correct constitution is vital to maintaining the structural integrity of the 900 kDa complex.
Reconstitution Guidelines
- Reconstitute utilizing only sterile, preservative-free 0.9% sodium chloride.
- Inject the diluent gently into the vial to prevent foaming, bubbling, or protein denaturation.
- The resulting mixture should be entirely clear and colorless.
Expert Tip: Clinical Advantages & Trial Data
Comparable to Botox®: Clinical comparisons show LetibotulinumtoxinA shares an identical 900 kDa molecular weight and pharmaceutical diffusion profile to OnabotulinumtoxinA (Botox).
Lower Target-Off Risk: Unlike 300-500 kDa toxins (like Dysport), the heavier 900 kDa structure drastically limits uncontrolled fluid diffusion. This localized action prevents unwanted muscle weakness in adjacent areas (e.g., ptosis).
Non-Inferiority Verified: Double-blind Phase III randomized trials for post-stroke spasticity proved Botulax is non-inferior to Botox in both safety and efficacy metrics.
Low Immunogenicity: Clinical studies revealed exceptional purity, with only one anti-drug antibody case observed, and crucially, zero neutralizing antibodies developed, preventing secondary treatment failure.
Visible Improvements (Before & After)
Documented aesthetic results underscore long-lasting patient satisfaction and dynamic wrinkle reduction. The following authentic clinical representations demonstrate the efficacy of Botulax across various facial zones.
Why Buy Botulax Bulk from Yaksu Medi?
As a leading Botulax supplier, we securely bridge the gap between South Korean manufacturers and global medical professionals for reliable Botox wholesale procurement.
- Authentic Supply: Direct sourcing guarantees FDA/EMA certified product integrity, complete with verifiable lot numbers.
- Cold Chain Integrity: We utilize advanced thermoregulated packaging to maintain the mandatory 2°C – 8°C environment right to your clinic doors.
- Unrivaled Market Positioning: Our strategic supply chain relies on direct manufacturer partnerships and high-volume procurement. By eliminating intermediary markups, we empower high-volume aesthetic centers and regional distributors with highly competitive B2B pricing structures.
- Global Export Expertise: Flawless management of commercial invoices and regulatory customs clearance to over 70 nations.
Storage, Shelf Life & Safety
Medical professionals must observe strict contraindications and temperature controls when utilizing this premium Botox.
Storage & Shelf Life
- Unopened Vials: Must be refrigerated between 2°C and 8°C (Cold Chain).
- Shelf Life: 36 months from the date of manufacture (certain therapeutic forms marked at 24 months).
- Post-Reconstitution: Store at 2°C – 8°C; microbiologically, it is strongly advised to use within 24 hours.
Safety & Contraindications
- Black Box Warning: As with all botulinum toxins, there is a remote risk of distant spread of toxin effect, potentially causing breathing or swallowing difficulties.
- Contraindications: Do not administer to patients with neuromuscular junction disorders (Myasthenia Gravis, Lambert-Eaton), pregnant/nursing mothers, or those with injection site infections.
- Common Side Effects: Headache is the most frequently reported. Others include localized pain/bruising, ptosis, and dry eyes.
R&D and Future Pipeline
Hugel, Inc. is actively expanding the LetibotulinumtoxinA portfolio. The current pipeline features cutting-edge delivery forms:
- HG102 (Liquid Toxin with Lidocaine): A ready-to-use liquid formulation without human serum albumin, removing the reconstitution step and reducing pain via Lidocaine. (Phase 1 completed).
- HG103 (Microneedle Toxin): A painless patch-type microneedle system geared towards resolving hyperhidrosis.
- HG105 (Pure 150 kDa Toxin): Stripping away the complex proteins to deliver a pure 150 kDa core, practically eliminating any risk of neutralizing antibody resistance.
Frequently Asked Questions (FAQ)
Is Botulax the same as Letybo?
Yes. Botulax is the brand name used primarily in South Korea and several international markets, while the exact same formulation is marketed as Letybo in the USA, Europe, and other specific regions. Both are manufactured by Hugel, Inc.
What is the difference between Botulax and standard American Botox?
Botulax (LetibotulinumtoxinA) and Botox (OnabotulinumtoxinA) share near-identical 900 kDa molecular characteristics and diffusion profiles. Clinical Phase III trials show Botulax is non-inferior (equivalent) in efficacy and safety to Botox, though Botulax often presents a more favorable ROI for clinics.
How should I store my Botulax stock?
Unopened vials must be kept strictly refrigerated between 2°C and 8°C. Once reconstituted, it should be kept at the same temperature and ideally used within 24 hours.
Are neutralizing antibodies a concern with Botulax?
Botulax features an extraordinarily high purity rate. Clinical safety studies revealed a negligible immunogenicity profile, showing zero development of neutralizing antibodies in observed patients, meaning the risk of secondary treatment failure is extremely low.
What is the minimum order quantity (MOQ) to buy Botulax wholesale?
MOQ and pricing vary based on your location, shipping requirements, and whether you are buying the 100 Unit, 200 Unit, or 300 Unit formats. Please click the WhatsApp button to request our current B2B tier pricing catalog.